Confirming the exact same problem on MSI GT70 laptop.
BSOD DRIVER_IRQL_NOT_LESS_OR_EQUAL (e22w8x64.sys) on attempt to install latest Skype as of 29-Jan-2013.
You can disable the Killer NIC service in Windows Services and delete the Bigfoot folder from the Startup directory then run Skype application.
05-02-2013 09:34 - edited 05-02-2013 09:35
One solution that works for me:
Go to Qualcomm Atherors Network Manager.
Left hand click on Applications tab
From the list scroll down to Skype.
Change Application priority to 3 = normal.
Restart skype. Solved.