Well, I have a problem with my box. When making Skype to Skype call after a few minutes (<10) the sound doesn't work anymore. Then I have to kill Skype because I can't close/quit it.
First I had Ubuntu 11.04 which I upgraded to 11.10 because I thought this might be the problem. Then I reinstalled fresh and the problem remains.
I have the same problem, with Ubuntu 11.10 (32 bits). Every time I have a conversation of more than ~5 min, Skype crashes. Also, my speakers get muted.
I don't think there is anything wrong with my sound settings. The problems seems to be very common. Perhaps it is general for Ubuntu 11.10 (32 bits).
[I] net-im/skype (126.96.36.199-r1@28-12-2011): A P2P-VoiceIP client.
[I] media-sound/pulseaudio (1.1-r1@16-12-2011): A networked sound server with an advanced plugin system
No audio since a couple weeks ago here too. Skype correctly recognizes PulseAudio, but I get no output (from the tests), and I can't even answer or initiate calls. If I change to an ALSA profile it works, but then ALSA locks the device and PulseAudio can't mix other streams to it.